There is a lot of hype around Cannabidiol (CBD), for very good reasons. CBD is one of two well-known major cannabinoids, potent substances with enormous therapeutic potential, causing quite a buzz among scientists, health professionals and patients who are using CBD-rich products to treat a wide range of conditions including anxiety, antibiotic-resistant infections, cancer, cardiovascular disease, chronic pain, Crohn’s, diabetes, multiple sclerosis, PTSD, rheumatoid arthritis, schizophrenia and more. However, legality, purity and potency get in the way of many realising any real relief from CBD. As a completely legal alternative, Copaiba (Copaifera reticulate) essential oil (EO), has the highest known botanical content of one of the most commonly found terpenes in Cannabis, beta-caryophyllene (BCP). Terpenes are produced in special secretory cells within the trichomes of the Cannabis plant, the nearly microscopic resinous stalks that cover the flowers and leaves. This is also where all cannabinoids, like THC and CBD, are created. About 20,000 terpenes exist in nature; around 200 have been identified in Cannabis.
BCP was first synthesised in 1964, but it wasn’t until 2008 that European scientists discovered it had cannabinoid-like properties. CBD has significant impacts on human health but doesn’t bind to cannabinoid receptors. BCP has many of the same health benefits as cannabinoids do, without binding to CB1 receptors. CB2 receptors are found throughout the body to which BCP’s bind, as evidenced in the 2013 study, Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception (antinociception is the process of blocking detection of a painful or injurious stimulus by sensory neurons). The abstract of the 2008 study, Beta-caryophyllene is a dietary cannabinoid, concludes;
“This natural product exerts cannabimimetic effects in vivo. These results identify (E)-BCP as a functional non-psychoactive CB2 receptor ligand in foodstuff and as a macrocyclic* anti-inflammatory cannabinoid in Cannabis”.
*Relating to or denoting a ring composed of a relatively large number of atoms, such as occur in chlorophyll and several natural antibiotics.
Due to targeting CB2 receptors, BCP is an effective way to medicate while avoiding any alteration in perception or motor skills. It can be used to treat several inflammatory disorders, including arthritis, multiple sclerosis and colitis. BCP has been shown to fight cancer, reduce anxiety and is gastroprotective, meaning it can be used to treat ulcers. There is a mountain of evidence to support the use of BCP for easing tension and discomfort, providing protective effects for kidney and liver systems, providing protection against auto-immune disruptions, easing depressive feelings and even helping to abstain from unhealthy habits such as alcohol dependence. Copaiba also shows skin-enhancing benefits. Applied directly to acne pimples and scars, it reduces inflammation and speeds up skin healing.
CB2 activation is correlated with the concentration of BCP’s. CBD oil is 35% BCP while Copaiba is 55%. This means even using high quality Cannabis oil it may be BCP doing all the work in easing health issues. Switching to Copaiba may afford even more relief and due to there being no THC, it won’t give a false positive on a drug test. BCP’s are in plenty of foods and other essential oils but nowhere near the concentration nor purity found in Copaiba. According to Dr Ethan B. Russo in his 2011 study, published in the British Journal of Pharmacology, Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects;
“β-Caryophyllene is generally the most common sesquiterpenoid encountered in cannabis … Caryophyllene is anti-inflammatory … comparable in potency to the toxic phenylbutazone and an essential oil (EO) containing it was on par with etodolac and indomethacin. In contrast to the latter agents, however, caryophyllene was a gastric cytoprotective, as had been claimed in the past in treating duodenal ulcers in the UK with Cannabis extract. Caryophyllene may have contributed to antimalarial effects as an EO component. Perhaps the greatest revelation regarding caryophyllene has been its demonstration as a selective full agonist at CB2”.
To get the amazing benefits of BCP from Copaiba EO, use it aromatically, apply topically to affected areas or internally, for example, use as a calmative before sleep, applying a few drops under the tongue (sublingually). CBD oil produced from hemp might not actually have much CBD whilst oils derived from Cannabis might contain THC and heavy metal traces, depending on the soil it was grown in and extraction techniques employed. If you want access to similar health benefits of as those provided by cannabinoids, a 15 ml bottle of Copaiba EO is competitively priced, hugely discounted in comparison to a 15 ml bottle of CBD oil!
Copaiba is a stimulant oleoresin obtained from the trunk of several pinnate-leaved South American leguminous trees found in the Amazon. Its medicinal use dates back to the 16th century when natives of Brazil used it as folk medicine. Today, Brazil produces approximately 95% of this oil-resin, exporting more than 500 tons each year. Sales of Copaiba are increasing, at least in part because more than 54 million American adults suffer from some form of arthritis and 23.7 million are limited in their usual activity primarily due to pain.
In Australia, 3.5 million (15% of) people have a form of arthritis, with the majority of those affected being of working age or younger. The conventional way to treat arthritis is using nonsteroidal anti-inflammatory drugs (NSAID’s) as well as cyclo-oxygenase-2 inhibitors (COXIB’s), which are not without adverse events like gastrointestinal bleeding, heart attacks and stroke. The side effects of NSAID’s and COXIB’s as well as warnings on the risks of gastrointestinal side effects, bleeding and cardiovascular disease all suggest the need to test novel therapies with potential clinical benefits and fewer side effects than available pharmaceuticals.
So, what plants are high in this CB2 agonist BCP? Well the James Duke ARS databse identifies many plants that have signficant amounts of BCP with the very highest being Celery. Herbs with BCP include Basil (Ocimum basilicum), Oregano (Origanum vulgare), Rosemary (Rosemarinus officinalis), Sage (Salvia officinalis) and Thyme (Thymus vulgaris). Spices as a source of BCP include Black Pepper (Piper nigrum), Cinnamon (Cinnamomum varieties) and Cloves (Syzgium aromaticum). If you’re working on inflammatory problems in the body, try a combination approach; combining CBD from hemp with traditional anti-inflammatory herbs. Alternatively, just include all of the above in your diet to support a healthy endocannabinoid system (ECS) response using food!
Expanded from Five Reasons Copaiba is Better Than CBD Oil with Copaiba: Silver bullet or snake oil?, BCP (Beta-Caryophyllene) : a potent CB2-agonist (anti-inflammatory) cannabinoid from food and Beta Caryophyllene (BCP): Cancer-Fighting Terpene